Antipsychotic drug exhibits cancer-fighting properties In a prime example of locating new uses for older drugs, research in zebrafish show that a 50-year-old antipsychotic medication called perphenazine can actively combat the cells of a difficult-to-treat type of acute lymphoblastic leukemia . The drug works by turning on a cancer-suppressing enzyme known as PP2A and causing malignant tumor cells to self-destruct sulbutiamine benefits more info . The findings claim that developing medicines that activate PP2A, while staying away from perphenazine’s psychotropic effects, could help clinicians make much-required headway against T-cell ALL, and other tumors aswell perhaps.
It’s possible that there is a window during which these compounds will continue to work, and if the intervention can be given after that time it won’t work, said Jinze Xu, Ph.D., first writer of the paper and a postdoctoral researcher at UF. The researchers will work to identify the perfect age at which various interventions can enhance behavioral or physical functionality. Very few studies have been done showing the effect of interventions on the outdated. Interestingly, although the old rats got no improvement in physical overall performance or mitochondrial function, that they had lowered levels of oxidative damage.